Low BCL-2 expression in acute leukemia with t(8;21) chromosomal abnormality

Chromosomal Abnormality in Men with Impaired Spermatogenesis

Bcl-2 oncoprotein expression in acute myeloid leukemia.

BACKGROUND In lymphoproliferative diseases the expression of Bcl-2, a mitochondrial oncoprotein capable of blocking apoptosis, is well-documented, while little research has been carried out on its distribution in myeloproliferative conditions. METHODS Using immunocytochemical methods, 63 cases of acute myeloid leukemia (AML) at onset and 10 relapses were studied to investigate Bcl-2 expressio...

Expression of ROR1 Gene in Patients with Acute Lymphoblastic Leukemia

Background: Acute lymphoblastic leukemia (ALL) results from genetic alterations in a single lymphoid progenitor cell. Expression of ROR1 is reported to be increased in ALL and mantle cell lymphoma. In this study the expression of ROR1 was assessed in newly diagnosed patients with ALL.  Methods: This study was carried out on 40 patients with newly diagnosed ALL and healthy individuals as contro...

Chromosomal abnormality of acute promyelocytic leukemia other than PML-RARA: a case report of acute promyelocytic leukemia with del(5q)

BACKGROUND The recent study described a better outcome in acute promyelocytic leukemia patients treated with all-trans retinoic acid and arsenic oxide compared to those treated with all-trans retinoic acid combined with conventional chemotherapy. The pivotal study indicated that favorable-risk acute promyelocytic leukemia patients can be cured without any cytotoxic chemotherapy. Even high-risk ...

A marrow chromosomal abnormality preceding clinical leukemia in Down's syndrome.

By ALAN P. DEMAYO, KOSMAS A. KIosSoGLoU, MARION E. ERLANDSON, REBECCA F. NOTTERMAN AND JAMES GERMAN DETECTION OF THE LEUKEMIC PROCESS before the usual clinical and hematologic features have appeared could be of value not only from the therapeutic standpoint but also in the understanding of the pathogenesis and evolution of the disease. In this respect, a better understanding of Down’s syndrome ...